Permanent Staff

  • Foto Pier Essay
    Pierangelo Metrangolo is Full Professor at Politecnico di Milano since 2011, where he is Executive Deputy Head of the Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”. He also holds a position as visiting professor at the Centre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials of Aalto University, Finland, and at the VTT-Technical Research Centre of Finland. His awards include the 2005 ‘‘G. Ciamician’’ medal of the Division of Organic Chemistry of the Italian Chemical Society, the 2005 Journals Grant Award of the Royal Society of Chemistry, the 2009 IUPAC Young Chemist Award, and the 2019 Fluorous Technologies Award. He is Chief of the Editorial Board of CrystEngComm (RSC), Co-Editor of Acta Crystallogr. B (IUCr), and Editorial Advisory Board member of Cryst. Growth Des. (ACS). He is author of 290 publications with 17686 citations (H-index: 60). He is currently Vice President of the Physical and Biophysical Chemistry Division (Div. I) of the IUPAC. Since 2013 he is European Research Council grantee with the projects “FOLDHALO – Folding with Halogen Bonding”, and “MINIRES – A Minimalist Elastomeric Peptide” aimed at investigating the relevance of biomolecular halogen bonds.

     

    Institutional webpage

    Orcid ID 0000-0002-7945-099X

  • Francesca
    Francesca Baldelli Bombelli is Associate Professor in Chemistry at the Politecnico di Milano. She has been Group Leader at the European Centre of Nanomedicine (CEN) in 2013-2015. In 2011-2014 she has been Lecturer in Nanotechnology and Colloid Science at the School of Pharmacy, UEA, Norwich, UK. She has been Post-Doc researcher: 2009-2011 at CBNI, University College of Dublin, Dublin, Ireland; 2006-2009 at the University of Florence; 2004-2006 at Chalmers University, Gothenburg, Sweden. She got her PhD in Chemical Sciences in 2004 at the University of Florence. Her main research interests are in the development of engineered nanomaterials (ENM) for the diagnosis and treatment of untreatable diseases. She is also interested in studying the complex processes occurring at the nano-bio interface between nanomaterials and biological matter.

    Institutional webpage

    Orcid ID 0000-0001-8138-9246
  • giancarlo1
    Giancarlo Terraneo (GT) obtained his Ph.D. in Chemistry in 2006 from University of Milan (Italy). GT is (since October 17, 2014) Associate Professor at the Department of Chemistry, Materials and Chemical Engineering "Giulio Natta" – Politecnico di Milano (Italy). He became Full Professor in November 2021. GT’s research interests are in the field of: crystal engineering, supramolecular chemistry, nano-materials and structural studies through X-ray diffraction techniques. GT is co-author of 83 articles/reviews (source Scopus, h-index 24), 1 patent (PCT) and 2 book chapters. GT has been the presenting author of more than 50 communications at international/national conferences. GT is university associate at the Center for Nano Science and Technology Center @ Polimi (CNST-IIT@Polimi) and CNR- Institute of Chemistry of Molecular Recognition (ICRM). GT is co-founder of Politecnico di Milano Spin-Off named "FluorIT S.r.l.". GT is organizer or co-organizer of international/national conferences and workshops.
     
  • Gabri
    Gabriella Cavallo is Associate Professor at Politecnico di Milano since 2012. She obtained her PhD in Chemistry in 2006 at the University of Salerno. After two years of activity in Pirelli Labs, a research unit of Pirelli S.p.A., she became post-doctoral researcher at Politecnico di Milano in 2008. She has been Team Leader at the Center of Nano Science and Technology of the Italian Institute of Technology in 2010-2011. In 2011 she has been visiting researcher at the VTT – Technical Research Centre of Finland. Since 2012 she is co-founder of FLUORIT, a Politecnico di Milano spin-off company for fluorine technologies. Her research activity is focused on the study of structure-property relationships of new fluorinated functional materials based on non-covalent interactions. She is also interested in the study of self-assembled systems based on proteins with high surface activity.


    Institutional web page

    Orcid ID 0000-0001-6387-9014
  • vale1Valentina Dichiarante is Associate Professor at Politecnico di Milano since December 2021. From 2016 she is Lecturer in Chemistry at the School of Architecture and Building Engineering of Politecnico di Milano. She has been post-doctoral researcher: 2012-2015 at Politecnico di Milano, 2010-2011 at Commissariat à l’Energie Atomique et aux Energies Alternatives CEA-Saclay (France), 2008-2009 at PhotoGreen Lab (University of Pavia). She obtained her Ph.D. in Chemistry in 2008 at the University of Pavia (Italy). Her current research interests are in: (i) design and synthesis of highly fluorinated ligands for the development of nanostructured theranostic platforms and functional materials; (ii) synthesis, optimization and characterization of supramolecular responsive materials, based on noncovalent interactions.

    Institutional web page

    Orcid ID 0000-0002-2977-5833
  • Foto CV dipartimento CPClaudia Pigliacelli is Junior Assistant Professor (RTD-A) at the 'Giulio Natta' Department of Chemistry, Materials and Chemical Engineering of the Politecnico di Milano and works in the SupraBioNanoLab research group since 2020. She received her PhD in Pharmacy from the University of East Anglia (UK) in 2015. She worked as research assistant and post-doc researcher at Politecnico di Milano (2013-2016), and as post-doc researcher at Aalto University (Finland, 2016-2019) and at the Centro de Investigaciones Cientifícas Avanzadas (CICA, Universidade da Coruña, Spain, 2020). In 2019 she was awarded the MSCA SEAL OF EXCELLENCE @ POLIMI fellowship. Her current research activity is focused on the design of self-assembled nanoscale systems based on peptides, inorganic nanoparticles and hybrid systems to be employed as drug carriers, diagnostic/theranostic tools and sensors. She is also skilled in the use of electron microscopy techniques for nanomaterials characterization.

    Institutional web page

    Orcid ID 0000-0002-0143-9045
 

FOLDHALO News

  • Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by ¹⁹F-MRI

    Dr. Cristina Chirizzi, Prof. Pierangelo Metrangolo, Prof. Francesca Baldelli Bombelli and others have recently published an article on Colloids and Surfaces B: Biointerfaces about the "Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by 19F-MRI".

    The full paper can be found at the following link: Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by 19F-MRI.

    Abstract. Fluorine-19 (19F) Magnetic Resonance Imaging (MRI) is an emergent imaging technique for molecular imaging and cell tracking. Lack of intrinsic 19F signals in tissues allows unambiguous in vivo detection of exogenous fluorinated probes, complementary to the anatomical and multiparametric information obtained by standard 1H-MRI. However, the intrinsic low sensitivity of MRI technique requires the need of designing increasingly effective fluorinated tracers. PERFECTA, with its 36 magnetically equivalent 19F atoms and a designed branched molecular structure, represents an excellent superfluorinated tracer. In this paper, we report the development of PERFECTA loaded PLGA NPs stabilized by different coatings as promising 19F-MRI probes. The results clearly show the optimal cellular uptake of the produced colloidally stable PERFECTA loaded PLGA NPs without impact on cells viability. Importantly, NPs stabilization with the anionic surfactant sodium cholate (NaC) clearly enhances NPs internalization within cells with respect to PVA-coated NPs. Moreover, the optimized NPs are characterized by shorter T1 relaxation times with respect to other PERFECTA formulations that would allow the increase of 19F-MRI sensitivity with fast imaging acquisitions.

     

    How to cite:
    Cristina Chirizzi, Lodovico Gatti, María Sancho-Albero, Victor Sebastian, Manuel Arruebo, Laura Uson, Giulia Neri, Jesus Santamaria, Pierangelo Metrangolo, Linda Chaabane, Francesca Baldelli Bombelli, Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by 19F-MRI, Colloids Surf. B, 2022, 112932
    DOI: https://doi.org/10.1016/j.colsurfb.2022.112932

     

  • Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

    Dr. Andrea Pizzi, Lorenzo Sori, Dr. Claudia Pigliacelli, Prof. Francesca Baldelli Bombelli, Prof. Pierangelo Metrangolo and others have recently published an article on Small about the "Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination".

    The full paper can be found at the following link: Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination.

    Abstract. Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.

     

    How to cite:
    Andrea Pizzi, Lorenzo Sori, Claudia Pigliacelli, Alfonso Gautieri, Clara Andolina, Greta Bergamaschi, Alessandro Gori, Pierre Panine, Antonio Mattia Grande, Markus B. Linder, Francesca Baldelli Bombelli, Monica Soncini and Pierangelo Metrangolo, Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination, Small, 2022, 2200807
    DOI: https://doi.org/10.1002/smll.202200807

     

  • Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights

    Lorenzo Sori, Dr. Andrea Pizzi, Prof. Giancarlo Terraneo, Prof. Pierangelo Metrangolo and others have recently published an article on CrystEngComm about "Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights".

    The full paper can be found at the following link: Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights.

    Abstract. Halogenation, generally introduced on aromatic amino acids, is becoming a key supramolecular tool in peptides. Herein, we report the crystal structures and DFT study of two bis-halogenated tyrosines showing the subtle relationship between hydrogen and halogen bonds in promoting their supramolecular self-assembly.

     

    How to cite:
    Lorenzo Sori, Andrea Pizzi, Nicola Demitri, Giancarlo Terraneo, Antonio Frontera and Pierangelo Metrangolo, Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights, CrystEngComm, 2022, d2ce00670g
    DOI: https://doi.org/10.1039/D2CE00670G

     

  • Online Participation to the 1st School of Supramolecular and Bio-Nanomaterials

    Do not miss the chance to participate online to the 1st School of Supramolecular and Bio-Nanomaterials

    Registration is still open at the following link: https://sbn.lakecomoschool.org/registration/.

    For information requests please contact the secretariat Chiara Stefanetti: This email address is being protected from spambots. You need JavaScript enabled to view it..

     

    School website: https://sbn.lakecomoschool.org.

    Additional information: Flyer

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