Permanent Staff

  • Foto Pier Essay
    Pierangelo Metrangolo is full professor at Politecnico di Milano since 2011, where he is Executive Deputy Head of the Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”. He also holds a position as visiting professor at the Centre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials of Aalto University, Finland, and at the VTT-Technical Research Centre of Finland. His awards include the 2005 ‘‘G. Ciamician’’ medal of the Division of Organic Chemistry of the Italian Chemical Society, the 2005 Journals Grant Award of the Royal Society of Chemistry, the 2009 IUPAC Young Chemist Award, and the 2019 Fluorous Technologies Award. He is Chief of the Editorial Board of CrystEngComm (RSC), Co-Editor of Acta Crystallogr. B (IUCr), and Editorial Advisory Board member of Cryst. Growth Des. (ACS). He is author of 290 publications with 17686 citations (H-index: 60). He is currently Vice President of the Physical and Biophysical Chemistry Division (Div. I) of the IUPAC. Since 2013 he is European Research Council grantee with the projects “FOLDHALO – Folding with Halogen Bonding”, and “MINIRES – A Minimalist Elastomeric Peptide” aimed at investigating the relevance of biomolecular halogen bonds.


    Institutional webpage

    Orcid ID 0000-0002-7945-099X

  • Francesca
    Francesca Baldelli Bombelli is associate Professor in Chemistry at the Politecnico di Milano. She has been Group Leader at the European Centre of Nanomedicine (CEN) in 2013-2015. In 2011-2014 she has been Lecturer in Nanotechnology and Colloid Science at the School of Pharmacy, UEA, Norwich, UK. She has been Post-Doc researcher: 2009-2011 at CBNI, University College of Dublin, Dublin, Ireland; 2006-2009 at the University of Florence; 2004-2006 at Chalmers University, Gothenburg, Sweden. She got her PhD in Chemical Sciences in 2004 at the University of Florence. Her main research interests are in the development of engineered nanomaterials (ENM) for the diagnosis and treatment of untreatable diseases. She is also interested in studying the complex processes occurring at the nano-bio interface between nanomaterials and biological matter.

    Institutional webpage

    Orcid ID 0000-0001-8138-9246
  • giancarlo1
    Giancarlo Terraneo (GT) obtained his Ph.D. in Chemistry in 2006 from University of Milan (Italy). GT is (since October 17, 2014) Associate Professor at the Department of Chemistry, Materials and Chemical Engineering "Giulio Natta" – Politecnico di Milano (Italy). GT’s research interests are in the field of: crystal engineering, supramolecular chemistry, nano-materials and structural studies through X-ray diffraction techniques. GT is co-author of 83 articles/reviews (source Scopus, h-index 24), 1 patent (PCT) and 2 book chapters. GT has been the presenting author of more than 50 communications at international/national conferences. GT is university associate at the Center for Nano Science and Technology Center @ Polimi (CNST-IIT@Polimi) and CNR- Institute of Chemistry of Molecular Recognition (ICRM). GT is co-founder of Politecnico di Milano Spin-Off named "FluorIT S.r.l.". GT is organizer or co-organizer of international/national conferences and workshops.

    Institutional webpage
  • Gabri
    Gabriella Cavallo is Assistant Professor at Politecnico di Milano since 2012. She obtained her PhD in Chemistry in 2006 at the University of Salerno. After two years of activity in Pirelli Labs, a research unit of Pirelli S.p.A., she became post-doctoral researcher at Politecnico di Milano in 2008. She has been Team Leader at the Center of Nano Science and Technology of the Italian Institute of Technology in 2010-2011. In 2011 she has been visiting researcher at the VTT – Technical Research Centre of Finland. Since 2012 she is co-founder of FLUORIT, a Politecnico di Milano spin-off company for fluorine technologies. Her research activity is focused on the study of structure-property relationships of new fluorinated functional materials based on non-covalent interactions. She is also interested in the study of self-assembled systems based on proteins with high surface activity.

    Institutional web page

    Orcid ID 0000-0001-6387-9014
  • vale1Valentina Dichiarante is Senior Assistant Professor (RTD-B) at Politecnico di Milano. From 2016 she is Lecturer in Chemistry at the School of Architecture and Building Engineering of Politecnico di Milano. She has been post-doctoral researcher: 2012-2015 at Politecnico di Milano, 2010-2011 at Commissariat à l’Energie Atomique et aux Energies Alternatives CEA-Saclay (France), 2008-2009 at PhotoGreen Lab (University of Pavia). She obtained her Ph.D. in Chemistry in 2008 at the University of Pavia (Italy). Her current research interests are in: (i) design and synthesis of highly fluorinated ligands for the development of nanostructured theranostic platforms and functional materials; (ii) synthesis, optimization and characterization of supramolecular responsive materials, based on noncovalent interactions.

    Institutional web page

    Orcid ID 0000-0002-2977-5833
  • Foto CV dipartimento CPClaudia Pigliacelli is Junior Assistant Professor (RTD-A) at the 'Giulio Natta' Department of Chemistry, Materials and Chemical Engineering of the Politecnico di Milano and works in the SupraBioNanoLab research group since 2020. She received her PhD in Pharmacy from the University of East Anglia (UK) in 2015. She worked as research assistant and post-doc researcher at Politecnico di Milano (2013-2016), and as post-doc researcher at Aalto University (Finland, 2016-2019) and at the Centro de Investigaciones Cientifícas Avanzadas (CICA, Universidade da Coruña, Spain, 2020). In 2019 she was awarded the MSCA SEAL OF EXCELLENCE @ POLIMI fellowship. Her current research activity is focused on the design of self-assembled nanoscale systems based on peptides, inorganic nanoparticles and hybrid systems to be employed as drug carriers, diagnostic/theranostic tools and sensors. She is also skilled in the use of electron microscopy techniques for nanomaterials characterization.

    Institutional web page

    Orcid ID 0000-0002-0143-9045
  • Maurizio modMaurizio Ursini is a Laboratory Technician at the Department of Chemistry, Materials and Chemical Engineering "G. Natta" of the Polytechnic of Milan since 1986. He collaborated with prof. Tullio Caronna to the synthesis of heteroaromatic compounds obtained by photochemical functionalization of heterocyclic bases and with prof. Dario Ghiringhelli to the synthesis of chiral synthons by enzymatic way. He currently collaborates with professors Pierangelo Metrangolo and Giuseppe Resnati to the preparation of halogen bond-based nanostructured materials.
    He is co-author of 22 publications in scientific journals and 1 book chapter.


  • A Bioorthogonal Probe for Multiscale Imaging by 19F-MRI and Raman Microscopy: From Whole Body to Single Cells

    Cristina Chirizzi, Francesca Baldelli Bombelli and Pierangelo Metrangolo have recently published an article on JACS about "A Bioorthogonal Probe for Multiscale Imaging by 19F-MRI and Raman Microscopy: From Whole Body to Single Cells".
    The full paper can be found at the following link: A Bioorthogonal Probe for Multiscale Imaging by 19F-MRI and Raman Microscopy: From Whole Body to Single Cells.

    Abstract. Molecular imaging techniques are essential tools for better investigating biological processes and detecting disease biomarkers with improvement of both diagnosis and therapy monitoring. Often, a single imaging technique is not sufficient to obtain comprehensive information at different levels. Multimodal diagnostic probes are key tools to enable imaging across multiple scales. The direct registration of in vivo imaging markers with ex vivo imaging at the cellular level with a single probe is still challenging. Fluorinated (19F) probes have been increasingly showing promising potentialities for in vivo cell tracking by 19F-MRI. Here we present the unique features of a bioorthogonal 19F-probe that enables direct signal correlation of MRI with Raman imaging. In particular, we reveal the ability of PERFECTA, a superfluorinated molecule, to exhibit a remarkable intense Raman signal distinct from cell and tissue fingerprints. Therefore, PERFECTA combines in a single molecule excellent characteristics for both macroscopic in vivo19F-MRI, across the whole body, and microscopic imaging at tissue and cellular levels by Raman imaging.


    How to cite the article:
    Cristina Chirizzi, Carlo Morasso, Alessandro Aldo Caldarone, Matteo Tommasini, Fabio Corsi, Linda Chaabane, Renzo Vanna, Francesca Baldelli Bombelli, and Pierangelo Metrangolo, A Bioorthogonal Probe for Multiscale Imaging by 19F-MRI and Raman Microscopy: From Whole Body to Single Cells, J. Am. Chem. Soc. 2021, 143, 31, 12253–12260


  • Waterproof-breathable films from multi-branched fluorinated cellulose esters

    Gabriella Cavallo, Valentina Dichiarante, Giancarlo Terraneo and Pierangelo Metrangolo have recently published an article on "Waterproof-breathable films from multi-branched fluorinated cellulose esters".
    The full paper can be found at the following link: Waterproof-breathable films from multi-branched fluorinated cellulose esters.

    Abstract. Cellulose ester films were prepared by esterification of cellulose with a multibranched fluorinated carboxylic acid, “BRFA” (BRanched Fluorinated Acid), at different anhydroglucose unit:BRFA molar ratios (i.e., 1:0, 10:1, 5:1, and 1:1). Morphological and optical analyses showed that cellulose-BRFA materials at molar ratios 10:1 and 5:1 formed flat and transparent films, while the one at 1:1 M ratio formed rough and translucent films. Degrees of substitution (DS) of 0.06, 0.09, and 0.23 were calculated by NMR for the samples at molar ratios 10:1, 5:1, and 1:1, respectively. ATR-FTIR spectroscopy confirmed the esterification. DSC thermograms showed a single glass transition, typical of amorphous polymers, at −11 °C. The presence of BRFA groups shifted the mechanical behavior from rigid to ductile and soft with increasing DS. Wettability was similar to standard fluoropolymers such as PTFE and PVDF. Finally, breathability and water uptake were characterized and found comparable to materials typically used in textiles.


    How to cite the article:
    Giacomo Tedeschi, Susana Guzman-Puyol, Luca Ceseracciu, José J. Benitez, Luca Goldoni, Andreas Koschella, Thomas Heinze, Gabriella Cavallo, Valentina Dichiarante, Giancarlo Terraneo, Athanassia Athanassiou, Pierangelo Metrangolo, José A. Heredia-Guerrero, Waterproof-breathable films from multi-branched fluorinated cellulose esters, Carbohydrate Polymers, 271, 2021, 118031


  • Halogen Bonding in Crystal Engineering Editor’s collection

    Pierangelo Metrangolo, Chair of the Editorial Board of CrystEngComm, has recently edited a collection of hot articles highlighting the contribution of the halogen bond to the field of crystal engineering.

    Introduce yourself to this collection by reading its presentation:

    "The halogen bond is the attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. Since its rediscovery in the early 2000s, the field of halogen bonding has boomed, becoming one of the most used chemical interactions in crystal engineering. This Editor’s collection highlights recent contributions to CrystEngComm that are broadly focused on halogen bonding in crystal engineering. The selection of articles showcases how the field has developed from the design of crystal structures to the development of functional materials. The wide range of halogen bond applications covers phosphorescent materials, pharmaceutical co-crystals and peptides, organic electronics, coordination frameworks, where the halogen bonds either drive the formation of the network, or stabilize it as a secondary interaction, or is used to bind hosted guests. Halogen bonding has become a mature field of research but its rediscovery has sparked interest towards other lesser known interactions, which are anticipated to become more prominent in the future, such as chalcogen, pnictogen, and tetrel bonds. 

    All of these articles are free to access until June 30th 2021 and we hope you enjoy reading them"

    The collection can be found at the followink link: Halogen Bonding in Crystal Engineering

  • Seeking PhD candidates for Marie Skłodowska-Curie European Industrial Doctorate (EID) programme

    Applications are welcome for an Early Stage Researcher (ESR) position associated with PhD-level research activities as part of the Marie Skłodowska-Curie European Industrial Doctorate (EID) programme related to the Consortium “REMEDI” (Trapping and Removal of X-ray Contrast Medium agents from water resource and stream Sediments New Concepts in Trapping, Recycling and Management). The latter leverages on a partnership between Politecnico di Milano (Italy), the University of Warwick (United Kingdom) and TAUW GMBH (Germany). The project will focus on the design and preparation of sorbent materials for the removal of iodinated contrast agents from water. We offer 1 full-time Marie Skłodowska-Curie scholarship, very competitive salary and relocation package, for a period of 36 months (40 hours per week), starting from November 2, 2021. Application deadline is May 20, 2021. For further info, please contact This email address is being protected from spambots. You need JavaScript enabled to view it. and visit


poli composito

Aalto nobg compres

vtt nobg compr