Permanent Staff

  • Foto Pier Essay
    Pierangelo Metrangolo is Full Professor at Politecnico di Milano since 2011, where he is Executive Deputy Head of the Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”. He also holds a position as visiting professor at the Centre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials of Aalto University, Finland, and at the VTT-Technical Research Centre of Finland. His awards include the 2005 ‘‘G. Ciamician’’ medal of the Division of Organic Chemistry of the Italian Chemical Society, the 2005 Journals Grant Award of the Royal Society of Chemistry, the 2009 IUPAC Young Chemist Award, and the 2019 Fluorous Technologies Award. He is Chief of the Editorial Board of CrystEngComm (RSC), Co-Editor of Acta Crystallogr. B (IUCr), and Editorial Advisory Board member of Cryst. Growth Des. (ACS). He is author of 290 publications with 17686 citations (H-index: 60). He is currently Vice President of the Physical and Biophysical Chemistry Division (Div. I) of the IUPAC. Since 2013 he is European Research Council grantee with the projects “FOLDHALO – Folding with Halogen Bonding”, and “MINIRES – A Minimalist Elastomeric Peptide” aimed at investigating the relevance of biomolecular halogen bonds.

     

    Institutional webpage

    Orcid ID 0000-0002-7945-099X

  • Francesca
    Francesca Baldelli Bombelli is Associate Professor in Chemistry at the Politecnico di Milano. She has been Group Leader at the European Centre of Nanomedicine (CEN) in 2013-2015. In 2011-2014 she has been Lecturer in Nanotechnology and Colloid Science at the School of Pharmacy, UEA, Norwich, UK. She has been Post-Doc researcher: 2009-2011 at CBNI, University College of Dublin, Dublin, Ireland; 2006-2009 at the University of Florence; 2004-2006 at Chalmers University, Gothenburg, Sweden. She got her PhD in Chemical Sciences in 2004 at the University of Florence. Her main research interests are in the development of engineered nanomaterials (ENM) for the diagnosis and treatment of untreatable diseases. She is also interested in studying the complex processes occurring at the nano-bio interface between nanomaterials and biological matter.

    Institutional webpage

    Orcid ID 0000-0001-8138-9246
  • giancarlo1
    Giancarlo Terraneo (GT) obtained his Ph.D. in Chemistry in 2006 from University of Milan (Italy). GT is (since October 17, 2014) Associate Professor at the Department of Chemistry, Materials and Chemical Engineering "Giulio Natta" – Politecnico di Milano (Italy). He became Full Professor in November 2021. GT’s research interests are in the field of: crystal engineering, supramolecular chemistry, nano-materials and structural studies through X-ray diffraction techniques. GT is co-author of 83 articles/reviews (source Scopus, h-index 24), 1 patent (PCT) and 2 book chapters. GT has been the presenting author of more than 50 communications at international/national conferences. GT is university associate at the Center for Nano Science and Technology Center @ Polimi (CNST-IIT@Polimi) and CNR- Institute of Chemistry of Molecular Recognition (ICRM). GT is co-founder of Politecnico di Milano Spin-Off named "FluorIT S.r.l.". GT is organizer or co-organizer of international/national conferences and workshops.
     
  • Gabri
    Gabriella Cavallo is Associate Professor at Politecnico di Milano since 2012. She obtained her PhD in Chemistry in 2006 at the University of Salerno. After two years of activity in Pirelli Labs, a research unit of Pirelli S.p.A., she became post-doctoral researcher at Politecnico di Milano in 2008. She has been Team Leader at the Center of Nano Science and Technology of the Italian Institute of Technology in 2010-2011. In 2011 she has been visiting researcher at the VTT – Technical Research Centre of Finland. Since 2012 she is co-founder of FLUORIT, a Politecnico di Milano spin-off company for fluorine technologies. Her research activity is focused on the study of structure-property relationships of new fluorinated functional materials based on non-covalent interactions. She is also interested in the study of self-assembled systems based on proteins with high surface activity.


    Institutional web page

    Orcid ID 0000-0001-6387-9014
  • vale1Valentina Dichiarante is Associate Professor at Politecnico di Milano since December 2021. From 2016 she is Lecturer in Chemistry at the School of Architecture and Building Engineering of Politecnico di Milano. She has been post-doctoral researcher: 2012-2015 at Politecnico di Milano, 2010-2011 at Commissariat à l’Energie Atomique et aux Energies Alternatives CEA-Saclay (France), 2008-2009 at PhotoGreen Lab (University of Pavia). She obtained her Ph.D. in Chemistry in 2008 at the University of Pavia (Italy). Her current research interests are in: (i) design and synthesis of highly fluorinated ligands for the development of nanostructured theranostic platforms and functional materials; (ii) synthesis, optimization and characterization of supramolecular responsive materials, based on noncovalent interactions.

    Institutional web page

    Orcid ID 0000-0002-2977-5833
  • Foto CV dipartimento CPClaudia Pigliacelli is Junior Assistant Professor (RTD-A) at the 'Giulio Natta' Department of Chemistry, Materials and Chemical Engineering of the Politecnico di Milano and works in the SupraBioNanoLab research group since 2020. She received her PhD in Pharmacy from the University of East Anglia (UK) in 2015. She worked as research assistant and post-doc researcher at Politecnico di Milano (2013-2016), and as post-doc researcher at Aalto University (Finland, 2016-2019) and at the Centro de Investigaciones Cientifícas Avanzadas (CICA, Universidade da Coruña, Spain, 2020). In 2019 she was awarded the MSCA SEAL OF EXCELLENCE @ POLIMI fellowship. Her current research activity is focused on the design of self-assembled nanoscale systems based on peptides, inorganic nanoparticles and hybrid systems to be employed as drug carriers, diagnostic/theranostic tools and sensors. She is also skilled in the use of electron microscopy techniques for nanomaterials characterization.

    Institutional web page

    Orcid ID 0000-0002-0143-9045
  • Maurizio modMaurizio Ursini is a Laboratory Technician at the Department of Chemistry, Materials and Chemical Engineering "G. Natta" of the Polytechnic of Milan since 1986. He collaborated with prof. Tullio Caronna to the synthesis of heteroaromatic compounds obtained by photochemical functionalization of heterocyclic bases and with prof. Dario Ghiringhelli to the synthesis of chiral synthons by enzymatic way. He currently collaborates with professors Pierangelo Metrangolo and Giuseppe Resnati to the preparation of halogen bond-based nanostructured materials.
    He is co-author of 22 publications in scientific journals and 1 book chapter.
 

FOLDHALO News

  • 1st School of Supramolecular and Bio-Nanomaterials

    Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a sketchy understanding of life itself”  
    Francis Crick (1988)

    The SupraBioNano resreach group is glad to announce its 1st School of Supramolecular and Bio-Nanomaterials!

    The field of supramolecular systems and bio-nanomaterials is both timely and highly interdisciplinary and this School wishes to foster a collaborative, multidisciplinary, and dynamic “playground” for presenting and discussing the most recent research results in field of supramolecular chemistry and self-assembled materials.

    This School aims to provide a research-led overview of the current state-of-the-art in self-assembly phenomena, applied supramolecular chemistry, and bio-nanomaterials. Taking inspiration from Nature, the attendees will be guided through all aspects of chemistry underpinning the formation of hierarchical structures and complex functionalities.

    The School is designed for PhD students, Post-Docs, and young scientists with various fields of interest, who aim at mastering the phenomena associated with molecular recognition and self-assembly, and the design and preparation of functional molecules and materials for a wide-range of high-end applications. During an intense training week the attendees will learn how to design and develop functional materials through the combination and assembly of organic, inorganic, coordination, biological molecules, and higher-level building units.

    Welcome to the 1stSchool
    of Supramolecular and Bio-Nanomaterials

    School Website: https://sbn.lakecomoschool.org/
    When: 13-17 June, 2022
    Where: Villa del Grumello, Via per Cernobbio (CO), Italy
    Additional information: Flyer

  • High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster

    Dr. Claudia PIgliacelli, Prof. Valentina Dichiarante, Prof. Francesca Baldelli Bombelli, Prof. Pierangelo Metrangolo, Prof. Giancarlo Terraneo and others have recently published an article on Nature Communications about "High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster".

    The full paper can be found at the following link: High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster.

    Abstract. Crystallization of atomically precise nanoclusters is gaining increasing attention, due to the opportunity of elucidating both intracluster and intercluster packing modes, and exploiting the functionality of the resulting highly pure crystallized materials. Herein, we report the design and single-crystal X-ray structure of a superfluorinated 20 kDa gold nanocluster, with an Au25 core coated by a shell of multi-branched highly fluorinated thiols (SF27) resulting in almost 500 fluorine atoms, i.e., ([Au25(SF27)18]0). The cluster shows a switchable solubility in the fluorous phase. X-ray analysis and computational studies reveal the key role of both intracluster and intercluster F···F contacts in driving [Au25(SF27)18]0 crystal packing and stabilization, highlighting the ability of multi-branched fluorinated thiols to endow atomically precise nanoclusters with remarkable crystallogenic behavior.

     

    How to cite:
    Claudia Pigliacelli, Angela Acocella, Isabel Díez, Luca Moretti, Valentina Dichiarante, Nicola Demitri, Hua Jiang, Margherita Maiuri, Robin H. A. Ras, Francesca Baldelli Bombelli, Giulio Cerullo, Francesco Zerbetto, Pierangelo Metrangolo & Giancarlo Terraneo, High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster, Nat Commun, 2022, 13, 2607
    DOI: https://doi.org/10.1038/s41467-022-29966-2

     

  • Janus-Type Dendrimers Based on Highly Branched Fluorinated Chains with Tunable Self-Assembly and 19F Nuclear Magnetic Resonance Properties

    Dr. Marta Rosati, Dr. Andrea Pizzi, Prof. Francesca Baldelli Bombelli, Prof. Gabriella Cavallo, Prof. Pierangelo Metrangolo and others have recently published an article on Macromolecules about "Janus-Type Dendrimers Based on Highly Branched Fluorinated Chains with Tunable Self-Assembly and 19F Nuclear Magnetic Resonance Properties".

    The full paper can be found at the following link: Janus-Type Dendrimers Based on Highly Branched Fluorinated Chains with Tunable Self-Assembly and 19F Nuclear Magnetic Resonance Properties.

    Abstract. Tuning the self-assembly of dendritic amphiphiles represents a major challenge for the design of advanced nanomaterials for biomimetic applications. The morphology of the final aggregates, in fact, critically depends on the primary structure of the dendritic building blocks as well as the environmental conditions. Here we report a new family of fluorinated Janus-type dendrimers (FJDs), based on a short-chain and branched fluorinated synthon with 27 magnetically equivalent fluorine atoms, linked to bis-MPA polyester dendrons of different generations. Increasing size, flexibility, and number of peripheral hydroxyl groups, we observed a peculiar self-assembly behavior in bulk and in aqueous media as a consequence of the subtle balance between their fluorinated and hydrophilic portions. The lowest generation FJDs formed spherical nanoparticles in water, e.g., micelles, showing a single 19F NMR peak with good signal-to-noise ratio and over time stability, making them promising as 19F-MRI traceable probes. The highest generation FJD, instead, presented an interesting morphological transition from multilamellar dendrimersomes to tubules as a consequence of a subtle balance of intra- and intermolecular forces that compete at the interface. Interestingly, a reduction of the local mobility of CF3 groups passing from dendrimersomes to tubules switches off the 19F NMR signal. The transition mechanism has been rationalized by coarse-grain simulations as well as demonstrated by using cosolvents of different nature (e.g., fluorinated) that promote conformational changes, ultimately reflected in the self-assembly behavior. Short and branched fluorinated chains have here been demonstrated as new moieties for the design of FJDs with tunable self-assembly behavior for potential applications as biocompatible 19F MRI probes in the construction of theranostic platforms.

     

    How to cite the article:
    Marta Rosati, Angela Acocella, Andrea Pizzi, Giorgio Turtù, Giulia Neri, Nicola Demitri, Nonappa, Giuseppina Raffaini, Bertrand Donnio, Francesco Zerbetto, Francesca Baldelli Bombelli, Gabriella Cavallo, and Pierangelo Metrangolo, Janus-Type Dendrimers Based on Highly Branched Fluorinated Chains with Tunable Self-Assembly and 19F Nuclear Magnetic Resonance Properties, Macromolecules, 2022, 55, 7, 2486-2496
    DOI: 10.1021/acs.macromol.2c00129

     

  • Fibril Structure Demonstrates the Role of Iodine Labelling on a Pentapeptide Self-Assembly

    All the authors would like to express their gratitude to Prof. Ulf Diederichsen, whose premature departure left us with a deep sorrow.

    Alessandro Marchetti, Dr. Andrea Pizzi, Dr. Claudia Pigliacelli, Prof. Pierangelo Metrangolo and others have recently published an article on Chemistry A European Journal about "Fibril Structure Demonstrates the Role of Iodine Labelling on a Pentapeptide Self-Assembly".
    The full paper can be found at the following link: Fibril Structure Demonstrates the Role of Iodine Labelling on a Pentapeptide Self-Assembly.

    Abstract. Iodination has long been employed as a successful labelling strategy to gain structural insights into proteins and other biomolecules via several techniques, including Small Angle X-ray Scattering, Inductively Coupled Plasma Mass Spectrometer (ICP-MS), and single-crystal crystallography. However, when dealing with smaller biomolecular systems, interactions driven by iodine may significantly alter their self-assembly behaviour. The engineering of amyloidogenic peptides for the development of ordered nanomaterials has greatly benefitted from this possibility. Still, to date, iodination has exclusively been applied to aromatic residues. In this work, an aliphatic bis-iodinated amino acid was synthesized and included into a custom pentapeptide, which showed enhanced fibrillogenic behaviour. Peptide single crystal X-ray structure and powder X-ray diffraction on its dried water solution demonstrated the key role of iodine atoms in promoting intermolecular interactions that drive the peptide self-assembly into amyloid fibrils. These findings enlarge the library of halogenated moieties available for directing and engineering the self-assembly of amyloidogenic peptides.

     

    How to cite the article:
    Alessandro Marchetti, Andrea Pizzi, Greta Bergamaschi, Nicola Demitri, Ulrike Stollberg, Ulf Diederichsen, Claudia Pigliacelli, Pierangelo Metrangolo, Fibril Structure Demonstrates the Role of Iodine Labelling on a Pentapeptide Self-Assembly, ChemEurJ, 2022, e202104089
    DOI: 10.1002/chem.202104089

     

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