Fibril Structure Demonstrates the Role of Iodine Labelling on a Pentapeptide Self-Assembly

Posted in Research article, 2022 on Monday, 23 May .

Alessandro Marchetti, Andrea Pizzi, Greta Bergamaschi, Nicola Demitri, Ulrike Stollberg, Ulf Diederichsen, Claudia Pigliacelli, Pierangelo Metrangolo

ChemEurJ 2022, 28, e202104089



An aliphatic bis-iodinated amino acid was synthesized and included into a custom pentapeptide, which showed enhanced fibrillogenic behaviour. Peptide single crystal X-ray structure and powder X-ray diffraction on its dried water solution demonstrated the key role of iodine atoms in promoting intermolecular interactions that drive the peptide self-assembly into amyloid fibrils.


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