Hydrophobin-Coated Solid Fluorinated Nanoparticles for ¹⁹F-MRI

Nazeeha Ayaz, Valentina Dichiarante, Claudia Pigliacelli, Jacopo Repossi, Lara Gazzera, Marta Boreggio, Daniele Maiolo, Cristina Chirizzi, Greta Bergamaschi, Linda Chaabane, Elisa Fasoli, Pierangelo Metrangolo, Francesca Baldelli Bombelli

Adv. Mater. Interfaces 2022, 2101677

DOI: https://doi.org/10.1002/admi.202101677

Ability of HFBII to form a rigid protein monolayer on superfluorinated coatings rendering them hydrophilic, a property retained in biological environment. This approach is then translated to directly disperse a solid superfluorinated ¹⁹F-MRI probe, PERFECTA, in aqueous solution through the formation of core-shell hydrophobin stabilized nanoparticles.