• Bio-Nanomaterials

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    Nanomedicine, “the application of nanotechnology to health” has been growing exponentially in the last two decades. In this regard, multifunctional nano-scaled materials have been developed for applications in fields such as drug delivery, diagnostics, biosensing and bioengineering.

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  • Crystal Engineering

    Crystal Engineering

    Crystal Engineering (CE) aims at understanding intermolecular interactions in the context of the crystal packing and utilize such understanding in the design and synthesis of new solid-state functional structures with desired physical and chemical properties.

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  • Fluorine Chemistry

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    Fluorinated chemicals find widespread use in hundreds of applications, such as anti-corrosion or anti-icing coatings, liquid-repellent textiles, oil/water separation, fire-fighting foams, paints, pharmaceuticals, and surfactants.

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  • Supramolecular Chemistry

    Supramolecular Chemistry

    Since its discovery, supramolecular chemistry has completely revolutionized the concept of synthesis, allowing for manipulation and production of nanostructured materials based on molecular components held together by noncovalent intermolecular forces.

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SupraBioNano Lab

SupraBioNano Logo h147pxWelcome to the Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNanoLab) where we take inspiration from Nature to engineer the self-assembly and self-organization of biomimetic supramolecular and nanostructured materials with applications ranging from crystal engineering to nanomedicine.

The SupraBioNanoLab

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FOLDHALO News

  • Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by ¹⁹F-MRI

    Dr. Cristina Chirizzi, Prof. Pierangelo Metrangolo, Prof. Francesca Baldelli Bombelli and others have recently published an article on Colloids and Surfaces B: Biointerfaces about the "Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by 19F-MRI".

    The full paper can be found at the following link: Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by 19F-MRI.

    Abstract. Fluorine-19 (19F) Magnetic Resonance Imaging (MRI) is an emergent imaging technique for molecular imaging and cell tracking. Lack of intrinsic 19F signals in tissues allows unambiguous in vivo detection of exogenous fluorinated probes, complementary to the anatomical and multiparametric information obtained by standard 1H-MRI. However, the intrinsic low sensitivity of MRI technique requires the need of designing increasingly effective fluorinated tracers. PERFECTA, with its 36 magnetically equivalent 19F atoms and a designed branched molecular structure, represents an excellent superfluorinated tracer. In this paper, we report the development of PERFECTA loaded PLGA NPs stabilized by different coatings as promising 19F-MRI probes. The results clearly show the optimal cellular uptake of the produced colloidally stable PERFECTA loaded PLGA NPs without impact on cells viability. Importantly, NPs stabilization with the anionic surfactant sodium cholate (NaC) clearly enhances NPs internalization within cells with respect to PVA-coated NPs. Moreover, the optimized NPs are characterized by shorter T1 relaxation times with respect to other PERFECTA formulations that would allow the increase of 19F-MRI sensitivity with fast imaging acquisitions.

     

    How to cite:
    Cristina Chirizzi, Lodovico Gatti, María Sancho-Albero, Victor Sebastian, Manuel Arruebo, Laura Uson, Giulia Neri, Jesus Santamaria, Pierangelo Metrangolo, Linda Chaabane, Francesca Baldelli Bombelli, Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by 19F-MRI, Colloids Surf. B, 2022, 112932
    DOI: https://doi.org/10.1016/j.colsurfb.2022.112932

     

  • Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

    Dr. Andrea Pizzi, Lorenzo Sori, Dr. Claudia Pigliacelli, Prof. Francesca Baldelli Bombelli, Prof. Pierangelo Metrangolo and others have recently published an article on Small about the "Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination".

    The full paper can be found at the following link: Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination.

    Abstract. Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.

     

    How to cite:
    Andrea Pizzi, Lorenzo Sori, Claudia Pigliacelli, Alfonso Gautieri, Clara Andolina, Greta Bergamaschi, Alessandro Gori, Pierre Panine, Antonio Mattia Grande, Markus B. Linder, Francesca Baldelli Bombelli, Monica Soncini and Pierangelo Metrangolo, Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination, Small, 2022, 2200807
    DOI: https://doi.org/10.1002/smll.202200807

     

  • Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights

    Lorenzo Sori, Dr. Andrea Pizzi, Prof. Giancarlo Terraneo, Prof. Pierangelo Metrangolo and others have recently published an article on CrystEngComm about "Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights".

    The full paper can be found at the following link: Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights.

    Abstract. Halogenation, generally introduced on aromatic amino acids, is becoming a key supramolecular tool in peptides. Herein, we report the crystal structures and DFT study of two bis-halogenated tyrosines showing the subtle relationship between hydrogen and halogen bonds in promoting their supramolecular self-assembly.

     

    How to cite:
    Lorenzo Sori, Andrea Pizzi, Nicola Demitri, Giancarlo Terraneo, Antonio Frontera and Pierangelo Metrangolo, Hydrogen and halogen bond synergy in the self-assembly of 3,5-dihalo-tyrosines: structural and theoretical insights, CrystEngComm, 2022, d2ce00670g
    DOI: https://doi.org/10.1039/D2CE00670G

     

  • Online Participation to the 1st School of Supramolecular and Bio-Nanomaterials

    Do not miss the chance to participate online to the 1st School of Supramolecular and Bio-Nanomaterials

    Registration is still open at the following link: https://sbn.lakecomoschool.org/registration/.

    For information requests please contact the secretariat Chiara Stefanetti: This email address is being protected from spambots. You need JavaScript enabled to view it..

     

    School website: https://sbn.lakecomoschool.org.

    Additional information: Flyer

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